Ad hoc and Fast Forward: The Science of Hormesis Growth and Development
نویسنده
چکیده
BACKGROUND Hormesis is a binary response phenomenon with low-dose stimulation (or inhibition) of effects by substances producing opposite high-dose responses. Hormesis, after decades of obscurity, has undergone a renaissance in recent years, with rapid growth benefiting greatly from the systematized efforts of such proponents as the hormesis group at the University of Massachusetts-Amherst led by Edward J. Calabrese. OBJECTIVE In this commentary I analyze chemical hormesis methodology with reference to ad hoc scientific approaches for defining and characterizing hormesis. DISCUSSIONS Proponents of hormesis have attempted a scientific characterization of hormesis through a battery of ad hoc methodologies using unvalidated criteria and other mechanisms for persistent database searches rather than through de novo hypothesis testing specific for hormesis. Here I discuss various scientific problems with this search-over-experiment approach, as well as other aspects of attempts at defining and characterizing the field. CONCLUSIONS Wide acceptance of hormesis by the broad scientific community and adoption of hormesis by public agencies for inclusion in health and regulatory policies have not occurred. Reasons may include the singular nature of hormesis research and directions followed in hormesis methodologies.
منابع مشابه
Hormesis: A Conversation with a Critic
OBJECTIVE In this commentary I respond to points raised in the commentary by Mushak [Ad hoc and fast forward: the science and control of hormesis growth and development. Environ Health Perspect 117:1333-1338 (2009)], which principally concerns studies by me and my colleagues concerning the frequency of hormesis in toxicology. DISCUSSION In this commentary I demonstrate that Mushak's analysis ...
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عنوان ژورنال:
دوره 117 شماره
صفحات -
تاریخ انتشار 2009